Born in the Lab
Apollo Neuroscience was born from research at the University of Pittsburgh. Drs. David Rabin MD, PhD and Greg Siegle PhD worked together at the Program in Cognitive Affective Neuroscience to develop and scientifically prove out the Apollo technology.
Together, they discovered that certain combinations of low frequency inaudible sound waves (vibration that you can feel, but can’t hear) can safely and reliably change how we feel through our sense of touch, and that we can measure those physiological changes in near real time.
After 5 years of development and testing Apollo in the lab and in the real world, we’re releasing Apollo publicly.
Stress Biology 101
Chronic stress makes us sick & makes it harder to recover
Have you ever felt like you had so much to do that you can’t focus on anything? Have you laid awake at night unable to sleep because your mind is racing? Have you had such a stressful day that your body feels run down and sore?
Chronic stress strains the whole body by over-activating our sympathetic nervous system (the fight-or-flight response), releasing stress hormones like cortisol, making our breathing shallow and fast, and sending our heart rates up and our HRV (Heart Rate Variability) down[1,2].
When the fight-or-flight response is active frequently it makes it physiologically harder to focus, meditate, relax, sleep, or even exercise because our body and mind are both signaling each other that we are under threat and need to be escaping danger, not sleeping or focusing on our work[1,2].
Sleep, meditation, relaxation practices and regular exercise help us to recover from stress by engaging the parasympathetic (rest and digest) nervous system, but they are all physically and mentally harder to do when we’re overwhelmed by chronic stress[1,2].

When left unchecked, chronic stress increases your risk of developing insomnia, anxiety-disorders, depression, and chronic pain[2-6]. Chronic stress exhausts us, makes us unhappy, disrupts our mood, causes tension and pain, and impairs our sleep.
How does chronic stress lower HRV and why does it matter?
Heart Rate Variability (HRV) measures the rate of change of the heart beat over time[2]. Having high HRV is a good thing. It means that your body can quickly adapt and recover from stress.
When we encounter stress in our environment, our heart rate, respiratory rate, and blood pressure should go up so we can quickly respond to a threat[1,2]. When we’re calm, our heart rate, respiratory rate, and blood pressure should be at comfortable resting rate. This is our body’s way of maintaining balance between thriving and surviving over time.
LOW HRV
Having consistently low HRV indicates that your body isn’t adapting to or recovering well from stress[2].
This could mean a number of things:
- You aren’t sleeping well
- You’ve exhausted your body
- You’re getting sick.
Those of us with consistently low HRV have a higher likelihood of developing:
- Injuries
- Insomnia
- Chronic pain
- Cardiovascular illness
- Anxiety-related disorders
- Depression
[2, 7-8, 10-13, 15-18, 20, 23]
HIGH HRV
High HRV indicates that your body is resilient, recovering well, and able to bounce back from stress quickly[2].
The following contribute to high HRV:
- Restorative sleep
- Mindfulness practice
- Balanced diet
- Regular exercise
- Healthy relationships
Those of us with consistently high HRV are more likely to have better:
- Focus
- Calm
- Performance (athletic and cognitive)
- Breathing
- Pain tolerance
- Blood pressure
- Sleep
- Resilience
[2, 9, 14, 15, 19, 21, 26-29]
HRV is the most reliable, non-invasive biometric of stress, measuring the balance between the parasympathetic and sympathetic systems[1,2].
Stress Biology 201
The autonomic nervous system governs all the activity in our body from our heart beat, blood pressure, respiratory rate, and hormones to our digestion, blood flow, how much sugar is in our blood, our vision, our reproduction, and the list goes on[1].
Our health and survival (no kidding) are dependent on the dynamic relationships between the two branches of the autonomic nervous system: the parasympathetic (rest and digest) branch and the sympathetic (fight or flight) branch [1].
Parasympathetic branch
The parasympathetic branch is responsible for conserving energy for when we need it next[1, 2]. It is activated by safety. When we are safe enough to sleep, meditate, listen to soothing music or experience soothing touch, our parasympathetic system engages, lowering our heart rate and blood pressure, improving our HRV (heart rate variability), and supporting reproduction, creativity, and energy recovery. This rest and relaxation are key so that we have enough energy to survive a threat whenever it comes.
Sympathetic branch
The purpose of our sympathetic “fight-or-flight” system is to kick in so we can survive a threat[1, 2]. When we experience a threat, whether that be a lion or a stressful email, our heart rate and blood pressure go up, blood rushes to the heart and to our muscles, our liver releases sugar into the blood, and digestion slows down so we can escape from whatever is threatening us and reach safety.

Left unchecked, stress increases the risk of developing chronic health conditions such as insomnia, anxiety disorders, depression, chronic pain, memory loss, metabolic disorders, cardiovascular disease, and even birth defects in our children[3-25]. Chronic stress also disrupts personal well-being, relationships, and sexual activity. As we all know, stress commonly interferes with our ability to be kind and good-natured with our family, co-workers, and our friends. While low HRV predicts poor sleep, focus, and an elevated risk of physical and mental illness, high HRV predicts resilience, consistent performance, better sleep, and lower chances of getting sick[2].
The Science Behind Apollo
Apollo uses waves of vibration that are demonstrated in both the lab and the real world to change the balance of our nervous systems through our sense of touch.
Here’s what we know from the Scientific Literature:
Touch changes how we feel, and science has proven it.
Touch is a powerful sense. Evolutionarily, it is the most important way that mammals communicate safety to one another[30-40]. Different forms of touch (vibration, electricity, heat, cold, soothing massage, etc) can change how we feel in ways that can be measured biologically. Extensive reports demonstrate that certain frequencies of vibration are found to be soothing and significantly increase parasympathetic tone, as measured by heart rate variability (HRV), while others can be more energizing, increasing our heart rate and other measures of sympathetic activity[2, 41-54].
What makes Apollo different from any vibration you’ve felt before?
It’s all about balance
Apollo isn’t just about relaxing, and it isn’t just about performing. Apollo is about physical and mental balance and we’ve designed each set of modes to help your body gently transition through your natural response to touch.
How? We combined frequencies of vibration known to change our energy levels by increasing or decreasing parasympathetic and sympathetic nervous system activity[41-54]. Modes designed for rest and relaxation contain more slow-moving gentle frequencies known to increase parasympathetic activity, the branch of your nervous system that is activated when you meditate, deep breathe, and sleep [2, 9, 14, 27-31]. Modes for energy contain vibration frequencies known in the literature to increase heart rate and blood flow for increased energy and alertness[2, 41-54].
Every single Apollo mode, whether it is designed to increase wakefulness or to help you fall asleep, is designed to restore your body by improving heart rate variability (HRV).
How does Apollo change HRV?
Apollo vibrations feel like waves coming and going. This sensation feels natural because it is. Apollo’s modes match a natural oscillation pattern between our heart and our lungs when we deep breathe, which consistently improves HRV in lab trials and in real world use. When our bodies feel the rhythm of the Apollo vibrations, it is automatically recognized by the body as soothing gentle touch, just like a friend giving you a hug on a bad day.
We’ve gone beyond the literature to independently test Apollo in academic-led trials.
Before we built Apollo, Dr. David Rabin MD, PhD and Dr. Greg Siegle PhD studied Apollo vibrations at the University of Pittsburgh. They went beyond the literature to test how Apollo vibrations would change the body in a double-blind randomized placebo-controlled crossover trial of 38 subjects at the University of Pittsburgh.
Preliminary findings suggest that the specific vibration patterns used in the Apollo technology increase the ability to focus and remain calm during periods of stress and that these specific vibration patterns improve the body’s ability to recover and be resilient to stress, as measured by HRV. These improvements in HRV are accompanied by proportionate improvements in cognitive and physical performance under stress.
Subsequent university pilots and trials have shown that Apollo consistently improves HRV under stress within 2-3 minutes, improves athletic recovery, and supports access to meditative states.
Check out our researchWhat we learned from over 2,000 tests in the real world
We studied the literature before we created Apollo’s frequencies. We tested Apollo’s frequencies in university trials before we built the product. Each and every program is based on our knowledge of the body’s response to vibration and we learned so much from listening to our real-world users. They told us how they felt, what they used Apollo for, and they shared their data.
And we listened – Apollo’s modes are organized based on the science of how our body responds to Apollo vibrations, Apollo trials in the lab, and the experiences of our users.
The Science Behind the Modes

Energy and Wake Up
“Energy and Wake Up” mode is designed to improve wakefulness and attention by combining frequencies of vibration known to gently elevate heart rate[41-47] with those vibrations shown to improve physical and mental recovery from stress, as measured by HRV[2, 48-54]. Apollo users typically use this mode in the morning and whenever they need a burst of energy.

Social and Open
“Social and Open” mode combines frequencies of vibration shown to improve recovery and HRV and to increase both energy levels and feelings of calm[2, 41-54]. They are designed to help you feel engaged and at ease. Apollo users typically use this mode most often for socializing and networking.

Clear and Focused
“Clear and Focused” mode combines frequencies of vibration shown to improve performance and HRV and to lower heart rate under stress[2, 42-54]. Scientific literature and university-led trials demonstrate that frequencies in the “Clear and Focused” mode improve focus and feelings of calm. Apollo users typically use this mode for cognitive and athletic performance and creative work.

Rebuild and Recover
“Rebuild and Recover” mode combines frequencies of vibration shown to improve HRV[2, 42-54]. Pilot trials show that these frequencies help us return to our natural resting heart rate, respiratory rate and blood pressure more quickly after physical and cognitive exertion. Apollo users typically use this mode for improved recovery from physical strain due to exercise, mental or emotional stress, or when feeling under the weather.

Meditation and Mindfulness
“Meditation and Mindfulness” mode combines frequencies of vibration shown to improve HRV[2, 48-54] with others shown to improve our awareness of our bodies[2, 27-33]. By helping the body and mind relax into one another, these frequencies help users ease into and reach deeper meditation states more easily. Apollo users also use this mode for relief from persistent soreness and tension.

Relax and Unwind
“Relax and Unwind” mode combines frequencies shown to support relaxation and recovery by increasing parasympathetic (rest and digest) activity in the nervous system and improving HRV [2, 27-33, 42-54]. Apollo users most often use this mode to unwind or before sleep.

Sleep and Renew
“Sleep and Renew” is the most gentle of the Apollo modes. Shown to improve parasympathetic activity and to aid in relaxation[2, 42-54], Apollo trial participants reported feeling sleepy within minutes of using these frequencies. “Sleep and Renew” mode is most often to help users fall asleep more easily, particularly after busy days, travel, and times of stress.
References
- Berntson GG, Quigley K, Lozano DL. Cardiovascular Psychophysiology. In: Cacioppo JT, Tassinary LG,
Berntson GG, editors. Handbook of psychophysiology. Fourth edition. ed. Cambridge, United Kingdom ;
New York, NY, USA: Cambridge University Press; 2017. p. xvi, 715 pages.
- Lehrer PM, Gevirtz R. Heart rate variability biofeedback: how and why does it work? Front Psychol.
2014;5:756. doi: 10.3389/fpsyg.2014.00756. PubMed PMID: 25101026; PubMed Central PMCID:
PMCPMC4104929.
- World Health Organization; https://www.who.int/mental_health/evidence/burn-out/en/
- Goh J, Pfeffer J, and Zenios SA. The relationship between workplace stressors and mortality and healthcare
costs in the United States. Management Science. 2016; 62(2): 4-7. https://doi.org/10.1287/mnsc.2014.2115 - Dusik D. Insomnia costing U.S. workforce $63.2 billion a year in lost productivity, study shows. American
Academy of Sleep Medicine. 2011. https://aasm.org/insomnia-costing-u-s-workforce-63-2-billion-a-year-in-lost-productivity-study-shows/ - How to tell if you’re close to burning out:
https://www.bbc.com/worklife/article/20190610-how-to-tell-if-youve-got-pre-burnout
- Dodds KL, Miller CB, Kyle SD, Marshall NS, Gordon CJ. Heart rate variability in insomnia patients: A
critical review of the literature. Sleep Med Rev. 2017 Jun;33:88-100. doi:
10.1016/j.smrv.2016.06.004. Epub 2016 Jun 28. Review. PubMed PMID: 28187954
- Gouin JP, Wenzel K, Boucetta S, O’Byrne J, Salimi A, Dang-Vu TT. High-frequency heart rate
variability during worry predicts stress-related increases in sleep disturbances. Sleep Med. 2015
May;16(5):659-64. Doi: 10.1016/j.sleep.2015.02.001. Epub 2015 Feb 7. PubMed PMID: 25819418
- Tsai HJ, Kuo TB, Lee GS, Yang CC. Efficacy of paced breathing for insomnia: enhances vagal activity
and improves sleep quality. Psychophysiology. 2015 Mar;52(3):388-96. doi: 10.1111/psyp.12333. Epub
2014 Sep 19. PubMed PMID: 25234581
- Rombold-Bruehl F, Otte C, Renneberg B, Schmied A, Zimmermann-Viehoff F, Wingenfeld K, Roepke S.
Lower heart rate variability at baseline is associated with more consecutive intrusive memories in
an experimental distressing film paradigm. World J Biol Psychiatry. 2017 Oct 12:1-6. Doi:
10.1080/15622975.2017.1372628. [Epub ahead of print] PubMed PMID: 29022753
- Dennis PA, Kimbrel NA, Sherwood A, Calhoun PS, Watkins LL, Dennis MF, Beckham JC. Trauma and
Autonomic Dysregulation: Episodic-Versus Systemic-Negative Affect Underlying Cardiovascular Risk in
Posttraumatic Stress Disorder. Psychosom Med. 2017 Jun;79(5):496-505. doi:
10.1097/PSY.0000000000000438. PubMed PMID: 28570433; PubMed Central PMCID: PMC5466498
- Lee SM, Han H, Jang KI, Huh S, Huh HJ, Joo JY, Chae JH. Heart rate variability associated with
posttraumatic stress disorder in victims’ families of sewol ferry disaster. Psychiatry Res. 2018
Jan;259:277-282. Doi: 10.1016/j.psychres.2017.08.062. Epub 2017 Aug 24. PubMed PMID: 29091829
- Dennis PA, Dedert EA, Van Voorhees EE, Watkins LL, Hayano J, Calhoun PS, Sherwood A, Dennis MF,
Beckham JC. Examining the Crux of Autonomic Dysfunction in Posttraumatic Stress Disorder: Whether
Chronic or Situational Distress Underlies Elevated Heart Rate and Attenuated Heart Rate Variability.
Psychosom Med. 2016 Sep;78(7):805-9. Doi: 10.1097/PSY.0000000000000326. PubMed PMID: 27057817;
PubMed Central PMCID: PMC5003742
- Wahbeh H, Goodrich E, Goy E, Oken BS. Mechanistic Pathways of Mindfulness Meditation in Combat
Veterans With Posttraumatic Stress Disorder. J Clin Psychol. 2016 Apr;72(4):365-83. doi:
10.1002/jclp.22255. Epub 2016 Jan 21. PubMed PMID: 26797725; PubMed Central PMCID: PMC4803530
- Lumley MA, Cohen JL, Borszcz GS, et al. Pain and Emotion: A Biopsychosocial Review of Recent
Research. Journal of Clinical Psychology. 2011;67(9):942-968. doi:10.1002/jclp.20816
- Koenig J, Loerbroks A, Jarczok MN, Fischer JE, Thayer JF. Chronic Pain and Heart Rate Variability in
a Cross-Sectional Occupational Sample: Evidence for Impaired Vagal Control. Clin J Pain. 2016
Mar;32(3):218-25. doi: 10.1097/AJP.0000000000000242. PubMed PMID: 25924095
- Koenig J, Falvay D, Clamor A, Wagner J, Jarczok MN, Ellis RJ, Weber C, Thayer JF. Pneumogastric
(Vagus) Nerve Activity Indexed by Heart Rate Variability in Chronic Pain Patients Compared to
Healthy Controls: A Systematic Review and Meta-Analysis. Pain Physician. 2016 Jan;19(1):E55-78.
Review. PubMed PMID: 26752494
- Kidwell M, Ellenbroek BA. Heart and soul: heart rate variability and major depression. Behav
Pharmacol. 2018 Apr;29(2 and 3 – Special Issue):152-164. Doi:10.1097/FBP.0000000000000387. PubMed
PMID: 29543649
- Park H, Oh S, Noh Y, Kim JY, Kim JH. Heart Rate Variability as a Marker of Distress and Recovery:
The Effect of Brief Supportive Expressive Group Therapy With Mindfulness in Cancer Patients. Integr
Cancer Ther. 2018 Feb 1:1534735418756192. doi: 10.1177/1534735418756192. [Epub ahead of print]
PubMed PMID: 29417836
- Williams S, Booton T, Watson M, Rowland D, Altini M. Heart Rate Variability is a Moderating Factor
in the Workload-Injury Relationship of Competitive CrossFit™ Athletes. J Sports Sci Med. 2017 Dec
1;16(4):443-449. eCollection 2017 Dec. PubMed PMID: 29238242; PubMed Central PMCID: PMC5721172
- Nuuttila OP, Nikander A, Polomoshnov D, Laukkanen JA, Häkkinen K. Effects of HRV-Guided vs.
Predetermined Block Training on Performance, HRV and Serum Hormones. Int J Sports Med. 2017
Nov;38(12):909-920. doi: 10.1055/s-0043-115122. Epub 2017 Sep 26. PubMed PMID: 28950399
- Lyytikäinen K, Toivonen L, Hynynen E, Lindholm H, Kyröläinen H. Recovery of rescuers from a 24-h
shift and its association with aerobic fitness. Int J Occup Med Environ Health. 2017 May
8;30(3):433-444. doi: 10.13075/ijomeh.1896.00720. Epub 2017 Apr 20. PubMed PMID: 28481376
- Kajaia T, Maskhulia L, Chelidze K, Akhalkatsi V, Kakhabrishvili Z. THE EFFECTS OF NON-FUNCTIONAL
OVERREACHING AND OVERTRAINING ON AUTONOMIC NERVOUS SYSTEM FUNCTION IN HIGHLY TRAINED ATHLETES.
Georgian Med News. 2017 Mar;(264):97-103. PubMed PMID: 28480859
- Peter R, Sood S, Dhawan A. Spectral Parameters of HRV In Yoga Practitioners, Athletes And Sedentary
Males. Indian J Physiol Pharmacol. 2015 Oct-Dec;59(4):380-7. PubMed PMID: 27530004
- Kiss O, Sydó N, Vargha P, Vágó H, Czimbalmos C, Édes E, Zima E, Apponyi G, Merkely G, Sydó T, Becker
D, Allison TG, Merkely B. Detailed heart rate variability analysis in athletes. Clin Auton Res. 2016
Aug;26(4):245-52. Doi: 10.1007/s10286-016-0360-z. Epub 2016 Jun 6. PubMed PMID: 27271053
- Pereira LA, Nakamura FY, Castilho C, Kitamura K, Kobal R, Cal Abad CC, Loturco I. The impact of
detraining on cardiac autonomic function and specific endurance and muscle power performances of
high-level endurance runners. J Sports Med Phys Fitness. 2016 Dec;56(12):1583-1591. Epub 2016 Mar 4.
PubMed PMID: 26986993
- Bernardi L, Wdowczyk-Szulc J, Valenti C, Castoldi S, Passino C, Spadacini G, et al. Effects of
controlled breathing, mental activity and mental stress with or without verbalization on heart rate
variability. Journal of the American College of Cardiology. 2000;35(6):1462-9. doi: Doi
10.1016/S0735-1097(00)00595-7. PubMed PMID: WOS:00008682870001
- McCaul KD, Solomon S, Holmes DS. Effects of paced respiration and expectations on physiological and psychological responses to threat. J Pers Soc Psychol.
- Harris VA, Katkin ES, Lick JR, Habberfield T. Paced respiration as a technique for the modification of autonomic response to stress. Psychophysiology. 1976;13(5):386-91. PubMed PMID: 972961
- Strigo IA, Craig AD. Interoception, homeostatic emotions and sympathovagal balance. Philos T R Soc B. 2016;371(1708). doi: ARTN 2016001010.1098/rstb.2016.0010. PubMed PMID: WOS:000387766300008
- Coan JA, Schaefer HS, Davidson RJ. Lending a hand: social regulation of the neural response to threat. Psychol Sci. 2006;17(12):1032-9. Epub 2007/01/05. doi: PSCI1832 [pii] 10.1111/j.1467-9280.2006.01832.x. PubMed PMID: 17201784
- Field T. Touch for socioemotional and physical well-being: A review. Dev Rev. 2010;30(4):367-83. doi: 10.1016/j.dr.2011.01.001. PubMed PMID: WOS:000289179900003
- Sliz D, Smith A, Wiebking C, Northoff G, Hayley S. Neural correlates of a single-session massage treatment. Brain Imaging Behav. 2012;6(1):77-87. doi: 10.1007/s11682-011-9146-z. PubMed PMID: 22261925; PubMed Central PMCID: PMCPMC3282900
- McGlone F, Wessberg J, Olausson H. Discriminative and affective touch: sensing and feeling. Neuron. 2014;82(4):737-55. doi: 10.1016/j.neuron.2014.05.001. PubMed PMID: 24853935
- Lindgren L, Gouveia-Figueira S, Nording ML, Fowler CJ. Endocannabinoids and related lipids in blood plasma following touch massage: a randomised, crossover study. BMC Res Notes. 2015;8:504. doi: 10.1186/s13104-015-1450-z. PubMed PMID: 26420002; PubMed Central PMCID: PMCPMC4589181
- Diego MA, Field T, Sanders C, Hernandez-Reif M. Massage therapy of moderate and light pressure and vibrator effects on EEG and heart rate. International Journal of Neuroscience. 2004;114(1):31-44. doi: 10.1080/00207450490249446. PubMed PMID: WOS:000188008300003
- Ahles TA, Tope DM, Pinkson B, Walch S, Hann D, Whedon M, et al. Massage therapy for patients undergoing autologous bone marrow transplantation. J Pain Symptom Manage. 1999;18(3):157-63. PubMed PMID: 10517036
- Hernandez-Reif M, Martinez A, Field T, Quintero O, Hart S, Burman I. Premenstrual symptoms are relieved by massage therapy. J Psychosom Obstet Gynaecol. 2000;21(1):9-15. PubMed PMID: 10907210
- Kim MS, Cho KS, Woo H, Kim JH. Effects of hand massage on anxiety in cataract surgery using local anesthesia. J Cataract Refract Surg. 2001;27(6):884-90. PubMed PMID: 11408136
- Ouchi Y, Kanno T, Okada H, Yoshikawa E, Shinke T, Nagasawa S, et al. Changes in cerebral blood flow under the prone condition with and without massage. Neurosci Lett. 2006;407(2):131-5. doi: 10.1016/j.neulet.2006.08.037. PubMed PMID: 16973270.
- Maikala RV, King S, Bhambhani YN. Acute physiological responses in healthy men during whole-body vibration. Int Arch Occup Environ Health. 2006;79(2):103-14. doi: 10.1007/s00420-005-0029-8. PubMed PMID: 16175416.
- Gojanovic B, Feihl F, Gremion G, Waeber B. Physiological response to whole-body vibration in athletes and sedentary subjects. Physiol Res. 2014;63(6):779-92. PubMed PMID: 25157652.
- Cochrane DJ, Sartor F, Winwood K, Stannard SR, Narici MV, Rittweger J. A comparison of the physiologic effects of acute whole-body vibration exercise in young and older people. Arch Phys Med Rehabil. 2008;89(5):815-21. doi: 10.1016/j.apmr.2007.09.055. PubMed PMID: 18452726.
- Uchikune M. The evaluation of horizontal whole-body vibration in the low frequency range. J Low Freq Noise V A. 2002;21(1):29-36. doi: Doi 10.1260/02630920260374961. PubMed PMID: WOS:000177739900004.
- Uchikune M. Study of the effects of whole-body vibration in the low frequency range. J Low Freq Noise V A. 2004;23(2):133-8. doi: Doi 10.1260/0263092042869801. PubMed PMID: WOS:000225283200005.
- Jiao K, Li Z, Chen M, Wang C, Qi S. Effect of different vibration frequencies on heart rate variability and driving fatigue in healthy drivers. Int Arch Occup Environ Health. 2004;77(3):205-12. doi: 10.1007/s00420-003-0493-y. PubMed PMID: 14762667.
- Bjor B, Burstrom L, Karlsson M, Nilsson T, Naslund U, Wiklund U. Acute effects on heart rate variability when exposed to hand transmitted vibration and noise. Int Arch Occup Environ Health. 2007;81(2):193-9. doi: 10.1007/s00420-007-0205-0. PubMed PMID: 17541625.
- Ma J, Zhang L, He G, Tan X, Jin X, Li C. Transcutaneous auricular vagus nerve stimulation regulates expression of growth differentiation factor 11 and activin-like kinase 5 in cerebral ischemia/reperfusion rats. J Neurol Sci. 2016;369:27-35. doi: 10.1016/j.jns.2016.08.004. PubMed PMID: 27653860.
- Bauer S, Baier H, Baumgartner C, Bohlmann K, Fauser S, Graf W, et al. Transcutaneous Vagus Nerve Stimulation (tVNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial (cMPsE02). Brain Stimul. 2016;9(3):356-63. doi: 10.1016/j.brs.2015.11.003. PubMed PMID: 27033012.
- Jiang Y, Li L, Ma J, Zhang L, Niu F, Feng T, et al. Auricular vagus nerve stimulation promotes functional recovery and enhances the post-ischemic angiogenic response in an ischemia/reperfusion rat model. Neurochem Int. 2016;97:73-82. doi: 10.1016/j.neuint.2016.02.009. PubMed PMID: 26964767.
- He B, Lu Z, He W, Huang B, Jiang H. Autonomic Modulation by Electrical Stimulation of the Parasympathetic Nervous System: An Emerging Intervention for Cardiovascular Diseases. Cardiovasc Ther. 2016;34(3):167-71. doi: 10.1111/1755-5922.12179. PubMed PMID: 26914959.
- Hideaki W, Tatsuya H, Shogo M, Naruto Y, Hideaki T, Yoichi M, et al. Effect of 100 Hz electroacupuncture on salivary immunoglobulin A and the autonomic nervous system. Acupunct Med. 2015;33(6):451-6. doi: 10.1136/acupmed-2015-010784. PubMed PMID: 26449884; PubMed Central PMCID: PMCPMC4860969.
- Stein C, Dal Lago P, Ferreira JB, Casali KR, Plentz RD. Transcutaneous electrical nerve stimulation at different frequencies on heart rate variability in healthy subjects. Auton Neurosci. 2011;165(2):205-8. doi: 10.1016/j.autneu.2011.07.003. PubMed PMID: 21827970.
- Hiraba H, Inoue M, Gora K, Sato T, Nishimura S, Yamaoka M, et al. Facial vibrotactile stimulation activates the parasympathetic nervous system: study of salivary secretion, heart rate, pupillary reflex, and functional near-infrared spectroscopy activity. Biomed Res Int. 2014;2014:910812. doi: 10.1155/2014/910812. PubMed PMID: 24511550; PubMed Central PMCID: PMCPMC3910479.