Apollo Neuro research

Read the research behind the results

Woman using Apollo app with Stealth Apollo on her wrist

The Apollo wearable’s efficacy has been validated in a number of independent and university-led trials, and there are more studies in progress focused on stress-related conditions. The Apollo Neuro team is excited to share these promising results in our mission to help people take control of their stress and live healthier, happier lives.

6
completed clinical trials
9
ongoing clinical trials
Apollo improves:
Sleep
Focus
Calm
Recovery
Heart rate variability

Completed studies and preliminary results

Improved quality of sleep

Preliminary results

Those who use the Apollo wearable consistently (3+ hours a day, 5+ days a week, during the day and night) over 3 months see the biggest improvements in sleep and cardiovascular recovery metrics.

19% average increase in deep sleep
14% average increase in REM sleep
6% average increase in total sleep time
4% average decrease in resting heart rate
11% average increase in HRV

Population

Apollo wearable users (18+)

Sample size

582

Primary outcomes

Sleep quality and cardiovascular metrics (heart rate, HRV) as measured by Oura Ring


Increased HRV and cognitive performance

Partner

University of Pittsburgh

Results

In a double-blind randomized placebo-controlled crossover clinical trial, Apollo vibrations improved heart rate variability (HRV) and cognitive performance under stress.

Up to 25% increase in focus and concentration
10% average increase in HRV

Population

Healthy adults (18+)

Sample size

38

Primary outcomes

Cognitive performance

Secondary outcomes

HRV, self-reported stress, pupil dilation, galvanic skin response, respirations, EEG


Less stress and burnout

Partner

Skilled nursing facility • Pittsburgh, PA

Results

In an open-label evaluation to improve employee wellness and quality of care in nursing home staff, the Apollo wearable reduced stress in nursing staff by 40% on average in two weeks.

40% less stress and anxiety, on average

Population

Nurses

Sample size

12

Primary outcome

Quality of life, mood, and stress symptoms


Easier access to meditation

Partner

University of Pittsburgh

Results

Both experienced and naive meditators achieve significantly deeper meditative states with the Apollo wearable.

50% faster access to meditative states for non-meditators, on average

Population

Healthy adults (18+)

Sample size

50 (25 experienced meditators, 25 without meditation experience)

Primary outcomes

Positive affect, HRV

Secondary outcomes

Negative affect, task performance, EEG


Improved athletic recovery and performance

Partner

Division 1 University Athletics Department

Results

In a study of collegiate athletes, the Apollo wearable improved heart rate variability (HRV), athletic performance and recovery.

>10% average faster physical recovery
10% average increase in HRV

Population

Collegiate athletes (18+)

Sample size

40

Primary outcomes

Athletic performance and recovery, cardiovascular metrics (HRV, heart rate)


Clinical Trial of Apollo to Improve Symptoms in PTSD

Partner

University of Pittsburgh

Results

Apollo use over 2 weeks significantly improved symptom scores in subjects with PTSD

Population

Adults with diagnosed PTSD (Ages 18-58)

Sample Size

16

Primary Outcomes

Change in PTSD symptoms and HRV before and after Apollo use.

Studies in progress

Open-Label Trial of Apollo in Veterans with Post-Traumatic Stress Disorder (PTSD)

Partner

Rocky Mountain VA Hospital, MIRECC for Suicide Prevention

Status

Recruitment Open (Local participants only)

Sample Size

100

Population

Veterans (age 18-65) eligible to receive care by a VA provider

Primary Outcomes

To test the acceptability and feasibility of the Apollo wearable system for managing symptoms in Veterans with PTSD.

Secondary Outcomes

Inflammatory biomarkers, microbiome, stress response gene expression.


Open-Label Clinical Trial of Apollo to Sustain Remission in Treatment-Resistant PTSD following MDMA-Assisted Therapy

Partner

The Board of Medicine

Status

Recruitment Open (Eligible Remote Participants)

Sample Size

200

Population

Any past participant in a MAPS trial of MDMA-assisted therapy who has completed their final follow up period with MAPS, including participants who received placebo and those who dropped out of the study prior to completion, are eligible to participate.

Primary Outcomes

To examine how use of Apollo can influence PTSD symptoms and remission rates over two years after participation in any MAPS trial of MDMA-assisted therapy.


Double-Blind Randomized Placebo-Controlled Trial of Apollo to Reduce Symptoms of ADHD/ADD

Partner

Michigan State University

Status

Recruitment Open (Local participants only)

Sample Size

100

Population

Children and Young Adults (7-17yo)

Primary Outcomes

To examine the effect of wearing Apollo on symptoms associated with ADHD.

Secondary Outcomes

To examine the effect of wearing Apollo on medication use associated with ADHD.


Remote Real World Observational Sleep Study of the Apollo Wearable

Partner

The Board of Medicine

Status

Recruitment Open (Eligible Remote participants)

Sample Size

6000

Population

Any Apollo wearable and Oura Ring user over age 18

Primary Outcomes

To examine the impact of Apollo usage on users' sleep and cardiovascular metrics as measured by validated survey tools and biometric data captured by the Oura Ring.


Open-Label Trial of Apollo for Treatment-Resistant Cancer Pain and Fatigue

Partner

University of Pittsburgh Medical Center

Status

Recruitment Open (Local participants only)

Sample Size

30

Population

Adults age 18-100 with metastatic breast cancer and fatigue

Primary Outcomes

To evaluate the efficacy and tolerability of the Apollo device in the management of fatigue and pain in patients with Metastatic Breast Cancer.


Open-Label Trial of Apollo to Reduce Fatigue in Systemic Sclerosis

Partner

University of Pittsburgh Medical Center

Status

Recruitment Open (Local participants only)

Sample Size

30

Population

Adults over age 18 with systemic sclerosis and fatigue

Primary Outcomes

The purpose of this study is to learn about the effect of Apollo on fatigue, Raynaud symptoms, depression, quality of life, and disease symptoms in patients with systemic sclerosis.


A Wearable Wrist-Worn Nerve Stimulator for Remediating Persistent Symptoms in Adolescents with PCS and Chronic Headache

Partner

University of South Carolina & The Board of Medicine

Status

Recruitment Open(Local Participants)

Sample Size

100

Population

Adolescents with PCS and Chronic Headache

Primary Outcomes

Examine how Apollo wearable use in participants with Post Concussion Syndrome (PCS) impacts their treatment outcomes in clinic and overall symptomatology.


Open-Label Trial of Apollo to Improve Recovery and Prevent Burnout in Physicians

Partner

University of Pittsburgh & University of California Los Angeles

Status

IRB Modification Pending

Sample Size

500

Population

Any physician currently in clinical practice or training at UPMC or UCLA

Primary Outcomes

This study is aimed at evaluating the impact of HRV-improving technology on physician well being, namely subjective and objective measures of stress and recovery among physicians.

Secondary Outcomes

Biometric data on cardiovascular fitness (HR/HRV) and sleep collected from Oura Ring and Apple Health.


Continuous Blood Pressure Monitoring with and without Vibratory Ankle Bracelet in Human Volunteers

Partner

BioActive (BAS)

Status

Recruitment Open

Sample Size

21

Population

General population age 18-65

Primary Outcomes

To examine if the Apollo wearable will reliably improve cardiovascular function in healthy subjects.

Secondary Outcomes

To examine whether heart rate variability (HRV) will change before and after the vibratory stimulation by Apollo.

If you’re a participant in an active study and you need assistance, please contact us at research@apolloneuro.com.