Read the research behind the results
The Apollo wearable’s efficacy has been validated in a number of independent and university-led trials, and there are more studies in progress focused on stress-related conditions. The Apollo Neuro team is excited to share these promising results in our mission to help people take control of their stress and live healthier, happier lives.
Completed studies and preliminary results
NEW: Apollo vibrations improve HRV in a double-blind randomized placebo-controlled crossover trial
Partner
University of Pittsburgh
Results
Statistically significant increase in HRV
Population
University of Pittsburgh club and varsity athletes
Sample size
22
Primary outcomes
Improved HRV, Faster recovery
Improved quality of sleep
Preliminary results
Those who use the Apollo wearable consistently (3+ hours a day, 5+ days a week, during the day and night) over 3 months see the biggest improvements in sleep and cardiovascular recovery metrics.
Population
Apollo wearable users (18+)
Sample size
582
Primary outcomes
Sleep quality and cardiovascular metrics (heart rate, HRV) as measured by Oura Ring
Increased HRV and cognitive performance
Partner
University of Pittsburgh
Results
In a double-blind randomized placebo-controlled crossover clinical trial, Apollo vibrations improved heart rate variability (HRV) and cognitive performance under stress.
Population
Healthy adults (18+)
Sample size
38
Primary outcomes
Cognitive performance
Secondary outcomes
HRV, self-reported stress, pupil dilation, galvanic skin response, respirations, EEG
Less stress and burnout
Partner
Skilled nursing facility • Pittsburgh, PA
Results
In an open-label evaluation to improve employee wellness and quality of care in nursing home staff, the Apollo wearable reduced stress in nursing staff by 40% on average in two weeks.
Population
Nurses
Sample size
12
Primary outcome
Quality of life, mood, and stress symptoms
Easier access to meditation
Partner
University of Pittsburgh
Results
Both experienced and naive meditators achieve significantly deeper meditative states with the Apollo wearable.
Population
Healthy adults (18+)
Sample size
50 (25 experienced meditators, 25 without meditation experience)
Primary outcomes
Positive affect, HRV
Secondary outcomes
Negative affect, task performance, EEG
Improved athletic recovery and performance
Partner
Division 1 University Athletics Department
Results
In a study of collegiate athletes, the Apollo wearable improved heart rate variability (HRV), athletic performance and recovery.
Population
Collegiate athletes (18+)
Sample size
40
Primary outcomes
Athletic performance and recovery, cardiovascular metrics (HRV, heart rate)
Clinical Trial of Apollo to Improve Symptoms in PTSD
Partner
University of Pittsburgh
Results
Apollo use over 2 weeks significantly improved symptom scores in subjects with PTSD
Population
Adults with diagnosed PTSD (Ages 18-58)
Sample Size
16
Primary Outcomes
Change in PTSD symptoms and HRV before and after Apollo use.
Studies in progress
Open-Label Trial of Apollo in Veterans with Post-Traumatic Stress Disorder (PTSD)
Partner
Rocky Mountain VA Hospital, MIRECC for Suicide Prevention
Status
Recruitment Open (Local participants only)
Sample Size
100
Population
Veterans (age 18-65) eligible to receive care by a VA provider
Primary Outcomes
To test the acceptability and feasibility of the Apollo wearable system for managing symptoms in Veterans with PTSD.
Secondary Outcomes
Inflammatory biomarkers, microbiome, stress response gene expression.
Open-Label Clinical Trial of Apollo to Sustain Remission in Treatment-Resistant PTSD following MDMA-Assisted Therapy
Partner
The Board of Medicine
Status
Recruitment Open (Eligible Remote Participants)
Sample Size
200
Population
Any past participant in a MAPS trial of MDMA-assisted therapy who has completed their final follow up period with MAPS, including participants who received placebo and those who dropped out of the study prior to completion, are eligible to participate.
Primary Outcomes
To examine how use of Apollo can influence PTSD symptoms and remission rates over two years after participation in any MAPS trial of MDMA-assisted therapy.
Double-Blind Randomized Placebo-Controlled Trial of Apollo to Reduce Symptoms of ADHD/ADD
Partner
Michigan State University
Status
Recruitment Open (Local participants only)
Sample Size
100
Population
Children and Young Adults (7-17yo)
Primary Outcomes
To examine the effect of wearing Apollo on symptoms associated with ADHD.
Secondary Outcomes
To examine the effect of wearing Apollo on medication use associated with ADHD.
Remote Real World Observational Sleep Study of the Apollo Wearable
Partner
The Board of Medicine
Status
Recruitment Open (Eligible Remote participants)
Sample Size
6000
Population
Any Apollo wearable and Oura Ring user over age 18
Primary Outcomes
To examine the impact of Apollo usage on users' sleep and cardiovascular metrics as measured by validated survey tools and biometric data captured by the Oura Ring.
Open-Label Trial of Apollo for Treatment-Resistant Cancer Pain and Fatigue
Partner
University of Pittsburgh Medical Center
Status
Recruitment Open (Local participants only)
Sample Size
30
Population
Adults age 18-100 with metastatic breast cancer and fatigue
Primary Outcomes
To evaluate the efficacy and tolerability of the Apollo device in the management of fatigue and pain in patients with Metastatic Breast Cancer.
Open-Label Trial of Apollo to Reduce Fatigue in Systemic Sclerosis
Partner
University of Pittsburgh Medical Center
Status
Recruitment Open (Local participants only)
Sample Size
30
Population
Adults over age 18 with systemic sclerosis and fatigue
Primary Outcomes
The purpose of this study is to learn about the effect of Apollo on fatigue, Raynaud symptoms, depression, quality of life, and disease symptoms in patients with systemic sclerosis.
A Wearable Wrist-Worn Nerve Stimulator for Remediating Persistent Symptoms in Adolescents with PCS and Chronic Headache
Partner
University of South Carolina & The Board of Medicine
Status
Recruitment Open(Local Participants)
Sample Size
100
Population
Adolescents with PCS and Chronic Headache
Primary Outcomes
Examine how Apollo wearable use in participants with Post Concussion Syndrome (PCS) impacts their treatment outcomes in clinic and overall symptomatology.
Open-Label Trial of Apollo to Improve Recovery and Prevent Burnout in Physicians
Partner
University of Pittsburgh & University of California Los Angeles
Status
Recruitment Open at UPMC
Sample Size
500
Population
Any physician currently in clinical practice or training at UPMC or UCLA
Primary Outcomes
This study is aimed at evaluating the impact of HRV-improving technology on physician well being, namely subjective and objective measures of stress and recovery among physicians.
Secondary Outcomes
Biometric data on cardiovascular fitness (HR/HRV) and sleep collected from Oura Ring and Apple Health.
Continuous Blood Pressure Monitoring with and without Vibratory Ankle Bracelet in Human Volunteers
Partner
BioActive (BAS)
Status
Recruitment Open
Sample Size
21
Population
General population age 18-65
Primary Outcomes
To examine if the Apollo wearable will reliably improve cardiovascular function in healthy subjects.
Secondary Outcomes
To examine whether heart rate variability (HRV) will change before and after the vibratory stimulation by Apollo.
