Apollo Neuro real-world PTSD study is complete

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The Background

Apollo Neuro co-founder Dr. Dave Rabin MD, PhD is a trauma-informed psychiatrist who has spent over 15 years studying chronic stress and working with clients with treatment-resistant mental health conditions that are worsened by stress. Many of the clients that Dr. Dave has worked with suffer from post-traumatic stress disorder (PTSD). PTSD is a disorder that can develop after a shocking, scary, or dangerous event and has been found to result in a sustained hyperactivity of the sympathetic (fight-or-flight) branch of the autonomic nervous system. 

PTSD is known to be related to fear conditioning, which results in an overactive fear response to situations that remind the individual of the original traumatic event [1,2,3]. To help clients extinguish fear and tap into feelings of safety, Dr. Dave’s psychotherapy protocols typically involve techniques like empathic listening and breathwork, which help signal safety to the brain and help establish the fertile ground for healing to take root. 

This led Dr. Dave to ask the question: what if there were other ways to create a feeling of safety - quickly and reliably, without as much effort or assistance from others? He began research and development in the lab at The University of Pittsburgh in 2014 to find a solution. And with that, the seed for the Apollo Neuro technology was planted. 

The Apollo wearable is currently being used by tens of thousands of people to aid in stress relief, for more relaxation, focus, and sleep. The wearable has also been studied in clinical trials in people who suffer from PTSD who seek that sense of security and control.

Open-label real-world PTSD Study

241 real-world Apollo users with self-reported PTSD volunteered to share information about their health, their symptoms, and their quality of life with the Apollo Neuroscience Research Team. Users reported on feelings of anxiety, restlessness, and improved attention, mood, sleep, and calm while using Apollo Neuro from 1-12 months.

Out of 241 real-world Apollo users who voluntarily self-reported PTSD: 96% (232 users) reported experiencing relief from using Apollo Neuro. 96% of users reported substantially reduced feelings of worry and restlessness, and improved attention, mood, and calm within 2 weeks of use.  90% of users also reported improved sleep with fewer nightmares and sleep disturbances.
Figure 1: Over 90% of real-world Apollo users who voluntarily self-reported PTSD reported improvements after using Apollo for 1 month or more.”

These results were consistent with the completed clinical trial at The University of Pittsburgh.

clinical trial of the Apollo wearable was just completed, focusing on understanding the relationship between symptoms of PTSD and soothing touch in a collaboration between the University of Pittsburgh and The New School in New York City. Read more about the study

What’s next:

Two more large clinical trials evaluating the Apollo wearable in PTSD patients are currently underway and recruiting participants.  The first at the Rocky Mountain VA in Denver, CO and the second, a nationwide trial, evaluating the Apollo wearable to sustain remission from PTSD following MDMA-assisted therapy. This second trial is open to anyone who has participated in a MAPS trial of MDMA-assisted therapy. Check your eligibility to participate

1. Morey RA, Dunsmoor JE, Haswell CC, Brown VM, Vora A, Weiner J, Stjepanovic D, Wagner HR 3rd; VA Mid-Atlantic MIRECC Workgroup, LaBar KS. Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder. Transl Psychiatry. 2015 Dec 15;5(12):e700. doi: 10.1038/tp.2015.196. PMID: 26670285; PMCID: PMC5068591.


2. Zhang X, Kim J, Tonegawa S. Amygdala Reward Neurons Form and Store Fear Extinction Memory. Neuron. 2020 Mar 18;105(6):1077-1093.e7. doi: 10.1016/j.neuron.2019.12.025. Epub 2020 Jan 14. PMID: 31952856.


3. Izquierdo I, Furini CR, Myskiw JC. Fear Memory. Physiol Rev. 2016 Apr;96(2):695-750. doi: 10.1152/physrev.00018.2015. PMID: 26983799.